Technology Offers
Peptide for improved pain management
During the postoperative recovery period adequate pain management - blocking nociception but allowing mobilisation - would be of advantage. Opioids do not affect sensory or motor neurons but are limited to systemic therapy because they cannot cross the paracellular barrier around peripheral nerve fibres when applied locally.
A claudin-1 derived peptide has been developed, which transiently opens the paracellular barrier allowing otherwise not permeable substances to reach peripheral nerve fibres by the paracellular route.
Stabilization of PPII-helical and α-helical peptides for targeted peptide design
For targeting protein-protein-interactions, the design and stabilization of peptide modulators is of great pharmacological interest. Here, two groups of novel compounds stabilizing or inducing either proline-rich PPII-helices or α-helix structures in proteins and peptides are described.
pH switchable tag for easy protein purification
The technology discloses a 32 AA long peptide and derivatives thereof as improved tags for easy purification of recombinant proteins. Oligomerisation of MB was shown to be reversibly switchable by changing the pH.
ISG15 KO mice
IFN-stimulated gene 15 (ISG15) is a ubiquitin homolog that is rapidly up-regulated after viral infection, and it conjugates to a wide array of host proteins. ISG15 KO mice show an altered host response to viral infection.
Peptide library of SH3-domain-derived protein drugs
Signalling via SH3 domain proteins plays an important role in the pathogenesis of many diseases. The domain is known to be structurally dependent on redox-dependent processes and oxidative stress, factors which are also important indicators and considerable risk factors in disease progression.
The polypeptide library is derived from the Src homology 3 (SH3) domain of the T cell protein ADAP (adhesion and degranulation promoting adapter protein), which holds a redox-dependent reversible structure switch in its SH3 protein interaction domain.
